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Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome.

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Title: Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome.
Authors: Huber H; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany., Arranz J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain., Arslan B; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden., Leuzy A; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Banner Sun Health Research Institute, Sun City, AZ, USA., Kittel O; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden., di Molfetta G; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden., Benejam B; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain., Videla L; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Barroeta I; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Soriano LDH; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain., Maure-Blesa L; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain., Rodríguez-Baz Í; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain., Arriola Infante JE; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Department of Neurology, Torrecárdenas University Hospital, Almería, Spain., Illán-Gala I; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Bejanin A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Montoliu-Gaya L; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden., Lleó A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Carmona-Iragui M; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain., Alcolea D; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Blennow K; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, Neurodegenerative Disorder Research Center, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China., Zetterberg H; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Fortea J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Ashton NJ; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden. nicholas.ashton@gu.se.; Banner Alzheimer's Institute, Phoenix, AZ, USA. nicholas.ashton@gu.se.; Banner Sun Health Research Institute, Sun City, AZ, USA. nicholas.ashton@gu.se.
Source: Nature communications [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9900. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-65882-x