Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.

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Title: Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.
Authors: Neo WH; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Fadlullah MZH; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Bhatnagar H; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Barone C; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Quattrini G; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Timóteo-Ferreira F; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Sala G; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Sellers R; Computational Biology Support, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Weightman J; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Breitwieser W; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Moncaut N; Genome Editing and Mouse Models, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Thambyrajah R; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Departamento de Biología Molecular, Facultad de Medicina, Universitat Cantabria, Santander, Spain., Jacobsen SEW; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge & Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden., Iqbal M; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Baker SM; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Azzoni E; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Lie-A-Ling M; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Michael.Lie-a-ling@cruk.manchester.ac.uk., Lacaud G; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Georges.Lacaud@cruk.manchester.ac.uk.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Dec; Vol. 4 (12), pp. 1642-1661. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-0590
DOI:10.1038/s44161-025-00740-z