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Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.

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Title: Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.
Authors: Neo WH; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Fadlullah MZH; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Bhatnagar H; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Barone C; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Quattrini G; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Timóteo-Ferreira F; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Sala G; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Sellers R; Computational Biology Support, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Weightman J; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Breitwieser W; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Moncaut N; Genome Editing and Mouse Models, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Thambyrajah R; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Departamento de Biología Molecular, Facultad de Medicina, Universitat Cantabria, Santander, Spain., Jacobsen SEW; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge & Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden., Iqbal M; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Baker SM; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Azzoni E; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Lie-A-Ling M; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Michael.Lie-a-ling@cruk.manchester.ac.uk., Lacaud G; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Georges.Lacaud@cruk.manchester.ac.uk.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Dec; Vol. 4 (12), pp. 1642-1661. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
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  Data: Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.
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  Data: <searchLink fieldCode="AU" term="%22Neo+WH%22">Neo WH</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Fadlullah+MZH%22">Fadlullah MZH</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Bhatnagar+H%22">Bhatnagar H</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Barone+C%22">Barone C</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Quattrini+G%22">Quattrini G</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Timóteo-Ferreira+F%22">Timóteo-Ferreira F</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Carrelha+J%22">Carrelha J</searchLink>; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sala+G%22">Sala G</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Sellers+R%22">Sellers R</searchLink>; Computational Biology Support, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Weightman+J%22">Weightman J</searchLink>; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Breitwieser+W%22">Breitwieser W</searchLink>; Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Moncaut+N%22">Moncaut N</searchLink>; Genome Editing and Mouse Models, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Thambyrajah+R%22">Thambyrajah R</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Departamento de Biología Molecular, Facultad de Medicina, Universitat Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Jacobsen+SEW%22">Jacobsen SEW</searchLink>; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge & Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Iqbal+M%22">Iqbal M</searchLink>; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Baker+SM%22">Baker SM</searchLink>; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Azzoni+E%22">Azzoni E</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Lie-A-Ling+M%22">Lie-A-Ling M</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Michael.Lie-a-ling@cruk.manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lacaud+G%22">Lacaud G</searchLink>; Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Georges.Lacaud@cruk.manchester.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229918284280206676%22">Nature cardiovascular research</searchLink> [Nat Cardiovasc Res] 2025 Dec; Vol. 4 (12), pp. 1642-1661. <i>Date of Electronic Publication: </i>2025 Nov 11.
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