IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy.

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Title: IgM Anti-Ganglioside Binding and Complement Activation in an iPSC-Derived Motor Neuron Model for Multifocal Motor Neuropathy.
Authors: Krijgsman D; Center for Translational Immunology, UMC Utrecht, the Netherlands., Dijkxhoorn K; Center for Translational Immunology, UMC Utrecht, the Netherlands., de Zeeuw E; Center for Translational Immunology, UMC Utrecht, the Netherlands., Bloemenkamp LM; Center for Translational Immunology, UMC Utrecht, the Netherlands.; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, Utrecht University, the Netherlands., Bos JW; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands., van Eijk RPA; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands., Van de Walle I; argenx, Ghent, Belgium., Huizinga R; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and., Jacobs BC; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and.; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Leusen JHW; Center for Translational Immunology, UMC Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, Utrecht University, the Netherlands., Hack CE; Center for Translational Immunology, UMC Utrecht, the Netherlands., Budding K; Center for Translational Immunology, UMC Utrecht, the Netherlands.; argenx, Ghent, Belgium., van der Pol WL; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, the Netherlands.
Source: Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2026 Jan; Vol. 13 (1), pp. e200482. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health/Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101636388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2332-7812 (Electronic) Linking ISSN: 23327812 NLM ISO Abbreviation: Neurol Neuroimmunol Neuroinflamm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2332-7812
DOI:10.1212/NXI.0000000000200482