Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

Saved in:
Bibliographic Details
Title: Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).
Authors: Spada F; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Gelsomino F; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Rinzivillo M; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy., Cinquini M; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Fittipaldo VA; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Tralongo A; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Moschetti I; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Albertelli M; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Ambrosini V; Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy; Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria, Bologna, Italy., Amoroso V; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Antonuzzo L; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Badalamenti G; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Bajetta E; Istituto di Oncologia, Policlinico di Monza, Monza, Italy., Baldari S; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy., Barberis M; Division of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy., Berruti A; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Bertani E; Division of Digestive Surgery IEO, European Institute of Oncology, IEO, IRCCS, ENETS and Center of Excellence, Milan, Italy., Bonomo G; Department of Interventional Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Bodei L; Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA., Buzzoni R; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Brizzi MP; Department of Oncology, 'San Luigi Gonzaga' University Hospital, University of Turin, Orbassano, Italy., Campana D; Department of Experimental Diagnostic and Specialized Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliera-Universitaria, Neuroendocrine Tumor Team Bologna, Bologna, Italy., Capurso G; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy., Casadei R; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy., Castellano M; Department of Internal Medicine and Endocrinology, University of Brescia, ASST Spedali Civili, Brescia, Italy., Cingarlini S; Department of Medicine, Oncology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy., Cives M; Interdisciplinary Department of Medicine, University 'Aldo Moro', Bari, Italy; Medical Oncology, AOU Consorziale Policlinico di Bari, Bari, Italy., Colao AM; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy; UNESCO Chair on Health Education and Sustainable Development, Federico II University, Naples, Italy., Coppa J; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Cremonini N; Endocrinology Clinics, Clinica Villalba, Bologna, Italy., Davì MV; Department of Medicine, Section of Endocrinology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy., De Angelis CG; Gastroenterology and Digestive Endoscopy Unit, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy., de Braud F; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, Università deli Studi di Milano, Milan, Italy., De Robertis R; Department of Radiology, G.B. Rossi Hospital, University of Verona, Verona, Italy., Faggiano A; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Falconi M; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy., Fassan M; Department of Medicine (DIMED), University of Padova, Padova, Italy; Veneto Institute of Oncology IOV-IRCCS, Padova, Italy., Ferolla P; NET Multidisciplinary Group, Umbria Regional Cancer Network, Perugia, Italy., Ferone D; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Filice A; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Fiore F; Onco Interventional Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Funicelli L; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Granata V; Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Giuffrida D; Oncologia Medica, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy., Grana CM; Division of Nuclear Medicine, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Grimaldi F; AME Past President, Udine, Italy., Ibrahim T; Osteoncology and Rare Tumor Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., La Salvia A; National Center for Drug Research and Evaluation, National Institute of Health (Istituto Superiore di Sanità, ISS), Rome, Italy., Laghi A; Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome-Radiology Unit-Sant'Andrea University Hospital, Rome, Italy., Luppi G; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Maccauro M; Department of Nuclear Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Marconcini R; Department of Medical Oncology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Massironi S; Fondazione IRCCS Policlinico, Divisione Gastroenterologia ed Endoscopia Digestiva, Milan, Italy., Mazzaferro V; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Merola E; Gastroenterology and Digestive Endoscopy Unit, Santa Chiara Hospital, Trento, Italy., Milione M; First Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Modica R; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Ortolani S; Department of Oncology, Ospedale P. Pederzoli, Peschiera del Garda, Italy., Papotti MG; Unit of Pathology, Città della Salute e della Scienza, Turin, Italy; Department of Oncology, University of Turin, Turin, Italy., Partelli S; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy., Pelosi G; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Pusceddu S; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Ramundo V; Departments of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Ravizza D; Division of Endoscopy, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Razzore P; SC Endocrinologia, Diabetologia e Malattie del Metabolismo, AO Ordine Mauriziano, Turin, Italy., Reimondo G; Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Ricci C; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Rindi G; Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; Anatomic Pathology Unit, Department of Woman and Child Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, ENETS Center of Excellence, Rome, Italy., Rizzo FM; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy., Rossi RE; Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, ENETS Center of Excellence, Milan, Italy., Tafuto S; Oncologia Clinica e Sperimentale Sarcomi e Tumori Rari, Istituto Nazionale Tumori IRCCS Fondazione Pascale, ENETS Center of Excellence, Naples, Italy., Tiberio GAM; General Surgery, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy., Versari A; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Vigorito R; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Zatelli MC; Department of Medical Sciences, Section of Endocrinology, Geriatrics and Internal Medicine, University of Ferrara, Ferrara, Italy., Di Maio M; Department of Oncology, University of Turin, A.O. Ordine Mauriziano, Turin, Italy., Perrone F; Clinical Trial Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Cinieri S; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy., Panzuto F; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: francesco.panzuto@uniroma1.it., Fazio N; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy. Electronic address: nicola.fazio@ieo.it.
Source: ESMO open [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105878. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article; Practice Guideline; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2059-7029
DOI:10.1016/j.esmoop.2025.105878