Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs.
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| Title: | Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs. |
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| Authors: | Chen CW; Department of Biomedical Engineering National Taiwan University Taipei City Taiwan.; Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital Taipei City Taiwan., Cheng YH; Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei City Taiwan., Yang KC; Department of Dental Technology, College of Oral Medicine Taipei Medical University Taipei City Taiwan., Huang CC; Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital Taipei City Taiwan., Hu MH; Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital Taipei City Taiwan., Sun YH; Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital Taipei City Taiwan., Wang JL; Department of Biomedical Engineering National Taiwan University Taipei City Taiwan., Yang SH; Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital Taipei City Taiwan. |
| Source: | JOR spine [JOR Spine] 2025 Nov 10; Vol. 8 (4), pp. e70135. Date of Electronic Publication: 2025 Nov 10 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Periodicals, Inc Country of Publication: United States NLM ID: 101722350 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-1143 (Electronic) Linking ISSN: 25721143 NLM ISO Abbreviation: JOR Spine Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2572-1143 |
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| DOI: | 10.1002/jsp2.70135 |
