Real-world safety and age-dependent effectiveness of vosoritide in achondroplasia: A single-center retrospective analysis of transition from growth hormone to vosoritide.

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Title: Real-world safety and age-dependent effectiveness of vosoritide in achondroplasia: A single-center retrospective analysis of transition from growth hormone to vosoritide.
Authors: Shimada T; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: t.shimada@ped.med.osaka-u.ac.jp., Nakayama H; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Oral and Maxillofacial Surgery, School & Graduate School of Dentistry, The University of Osaka, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: nkhirofumi@ped.med.osaka-u.ac.jp., Ueda I; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: i.ueda@ped.med.osaka-u.ac.jp., Ishimi T; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: takeshi.ishimi517@ped.med.osaka-u.ac.jp., Yamada C; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: c.yamada@ped.med.osaka-u.ac.jp., Nakano Y; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: yuccayuka1977@gmail.com., Yamamoto K; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Division of Health Sciences, The University of Osaka Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: ken.y.2015@ped.med.osaka-u.ac.jp., Fujiwara M; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: makotof@ped.med.osaka-u.ac.jp., Kitaoka T; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Pediatrics, ISEIKAI International General Hospital, 4-14 Minamiogi-machi, Kita-ku, Osaka, Osaka, 530-0052, Japan. Electronic address: tkitaoka@ped.med.osaka-u.ac.jp., Ozono K; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Center for Promoting Treatment of Intractable Diseases, ISEIKAI International General Hospital, 4-14 Minamiogi-machi, Kita-ku, Osaka, Osaka, 530-0052, Japan. Electronic address: keioz@ped.med.osaka-u.ac.jp., Kubota T; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Pediatric Nephrology and Metabolism, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, 840 Murodocho, Izumi, Osaka, 594-1101, Japan. Electronic address: kubotat@wch.opho.jp., Ohata Y; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: yasuhisa1@ped.med.osaka-u.ac.jp., Kitabatake Y; Department of Pediatrics, The University of Osaka Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: ykitaba@ped.med.osaka-u.ac.jp.
Source: Bone [Bone] 2026 Feb; Vol. 203, pp. 117722. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2763
DOI:10.1016/j.bone.2025.117722