Fc-Modified IVIG with Enhanced Blood-Brain Barrier Penetration Ameliorates Cognitive Deficits and Neuropathology in A53T α-Synuclein Transgenic Mice.

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Title: Fc-Modified IVIG with Enhanced Blood-Brain Barrier Penetration Ameliorates Cognitive Deficits and Neuropathology in A53T α-Synuclein Transgenic Mice.
Authors: Zhu J; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Huang YR; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China., Wang MQ; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Liang SY; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Yu XL; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China., Zhang GF; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. gfzhang@ipe.ac.cn., Liu RT; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. rtliu@ipe.ac.cn.
Source: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2025 Nov 14; Vol. 45 (1), pp. 103. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-6830
DOI:10.1007/s10571-025-01626-1