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B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape.

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Title: B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape.
Authors: Van der Vreken A; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Meeus F; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Tu C; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., van den Broecke L; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Raimondi V; Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy., Vescovini R; Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy., Hanssens H; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Watté F; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Autaers D; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Aragon MM; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Billiau J; Faculty of Medicine, KU Leuven, Leuven, Belgium., De Veirman K; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Vanderkerken K; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., De Vlaeminck Y; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Franceschini L; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Lee H; Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada., Neri P; Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada., De Bruyne E; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium., Storti P; Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy., Giuliani N; Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy., Breckpot K; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. karine.breckpot@vub.be., Menu E; Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. eline.menu@vub.be.
Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Nov 14; Vol. 18 (1), pp. 103. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1756-8722
DOI:10.1186/s13045-025-01756-5