A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.

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Title: A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.
Authors: Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany. Electronic address: zarbock@uni-muenster.de., Ostermann M; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK., Forni L; Department of Critical Care, Royal Surrey Hospital, Guildford, UK; School of Medicine, University of Surrey, Guildford, UK., Bode C; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Wild L; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Putensen C; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Roux DP; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain., Martín EE; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain., Arndt C; Department of Anesthesiology and Intensive Care Medicine, Medical Faculty, Philipps-University Marburg, Marburg, Germany., Rahmel T; Department of Anaesthesiology, Intensive Care and Pain Medicine, Knappschaft Kliniken, University Hospital Bochum, Bochum, Germany., de Rosa S; Department of Anesthesiology and Intensive Care, San Bortolo Hospital, Vicenza, Italy; Centre for Medical Sciences, University of Trento, Trento, Italy., Monard C; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Service d'anesthesie-reanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Schneider AG; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Glass A; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Jung-König M; Department of Anesthesiology, Medical Faculty Heidelberg University, Heidelberg, Germany., Romagnoli S; Department of Health Science, University of Florence, Florence, Italy; Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Gossage J; Department of Surgery, Guy's & St Thomas' NHS Foundation Trust, School of Cancer, King's College London, London, UK., Lumlertgul N; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK., Haaker JG; Department of Anesthesiology and Intensive Care Medicine, St Franziskus Hospital Münster, Münster, Germany., Ripollés-Melchor J; Infanta Leonor University Hospital, Madrid, Spain; Complutense University of Madrid, Madrid, Spain., Spadaro S; Department of Translational Medicine, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, Ferrara, Italy., Siniscalchi A; Postoperative and Abdominal Organ Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy., Futier E; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France., Aupetitgendre L; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France., Bhathal IR; Servei d'Anestesiologia i Reanimació, Hospital del Mar, Barcelona, Spain., Álvarez RG; Department of Anesthesiology and Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain., Bernard A; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Rosenberger P; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Wempe C; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Sadjadi M; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Meersch M; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Fischhuber K; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Bellomo R; Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia., Kellum JA; Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA., von Groote T; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Corporate Authors: BigpAK-2 study group
Source: Lancet (London, England) [Lancet] 2025 Dec 13; Vol. 406 (10521), pp. 2782-2791. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Adaptive Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-547X
DOI:10.1016/S0140-6736(25)01717-9