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A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.

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Title: A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.
Authors: Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany. Electronic address: zarbock@uni-muenster.de., Ostermann M; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK., Forni L; Department of Critical Care, Royal Surrey Hospital, Guildford, UK; School of Medicine, University of Surrey, Guildford, UK., Bode C; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Wild L; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Putensen C; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Roux DP; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain., Martín EE; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain., Arndt C; Department of Anesthesiology and Intensive Care Medicine, Medical Faculty, Philipps-University Marburg, Marburg, Germany., Rahmel T; Department of Anaesthesiology, Intensive Care and Pain Medicine, Knappschaft Kliniken, University Hospital Bochum, Bochum, Germany., de Rosa S; Department of Anesthesiology and Intensive Care, San Bortolo Hospital, Vicenza, Italy; Centre for Medical Sciences, University of Trento, Trento, Italy., Monard C; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Service d'anesthesie-reanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Schneider AG; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Glass A; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Jung-König M; Department of Anesthesiology, Medical Faculty Heidelberg University, Heidelberg, Germany., Romagnoli S; Department of Health Science, University of Florence, Florence, Italy; Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Gossage J; Department of Surgery, Guy's & St Thomas' NHS Foundation Trust, School of Cancer, King's College London, London, UK., Lumlertgul N; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK., Haaker JG; Department of Anesthesiology and Intensive Care Medicine, St Franziskus Hospital Münster, Münster, Germany., Ripollés-Melchor J; Infanta Leonor University Hospital, Madrid, Spain; Complutense University of Madrid, Madrid, Spain., Spadaro S; Department of Translational Medicine, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, Ferrara, Italy., Siniscalchi A; Postoperative and Abdominal Organ Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy., Futier E; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France., Aupetitgendre L; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France., Bhathal IR; Servei d'Anestesiologia i Reanimació, Hospital del Mar, Barcelona, Spain., Álvarez RG; Department of Anesthesiology and Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain., Bernard A; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Rosenberger P; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Wempe C; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Sadjadi M; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Meersch M; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Fischhuber K; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Bellomo R; Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia., Kellum JA; Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA., von Groote T; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Corporate Authors: BigpAK-2 study group
Source: Lancet (London, England) [Lancet] 2025 Dec 13; Vol. 406 (10521), pp. 2782-2791. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Adaptive Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Zarbock+A%22">Zarbock A</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany. Electronic address: zarbock@uni-muenster.de.<br /><searchLink fieldCode="AU" term="%22Ostermann+M%22">Ostermann M</searchLink>; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Forni+L%22">Forni L</searchLink>; Department of Critical Care, Royal Surrey Hospital, Guildford, UK; School of Medicine, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Bode+C%22">Bode C</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wild+L%22">Wild L</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Putensen+C%22">Putensen C</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Roux+DP%22">Roux DP</searchLink>; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martín+EE%22">Martín EE</searchLink>; Department of Anesthesiology and Critical Care Medicine, Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Arndt+C%22">Arndt C</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Medical Faculty, Philipps-University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rahmel+T%22">Rahmel T</searchLink>; Department of Anaesthesiology, Intensive Care and Pain Medicine, Knappschaft Kliniken, University Hospital Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22de+Rosa+S%22">de Rosa S</searchLink>; Department of Anesthesiology and Intensive Care, San Bortolo Hospital, Vicenza, Italy; Centre for Medical Sciences, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Monard+C%22">Monard C</searchLink>; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Service d'anesthesie-reanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Schneider+AG%22">Schneider AG</searchLink>; Service de Medecine Intensive Adulte, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Glass+A%22">Glass A</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Jung-König+M%22">Jung-König M</searchLink>; Department of Anesthesiology, Medical Faculty Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Romagnoli+S%22">Romagnoli S</searchLink>; Department of Health Science, University of Florence, Florence, Italy; Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Gossage+J%22">Gossage J</searchLink>; Department of Surgery, Guy's & St Thomas' NHS Foundation Trust, School of Cancer, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lumlertgul+N%22">Lumlertgul N</searchLink>; Department of Intensive Care, Guy's & St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Haaker+JG%22">Haaker JG</searchLink>; Department of Anesthesiology and Intensive Care Medicine, St Franziskus Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Ripollés-Melchor+J%22">Ripollés-Melchor J</searchLink>; Infanta Leonor University Hospital, Madrid, Spain; Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Spadaro+S%22">Spadaro S</searchLink>; Department of Translational Medicine, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Siniscalchi+A%22">Siniscalchi A</searchLink>; Postoperative and Abdominal Organ Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Futier+E%22">Futier E</searchLink>; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Aupetitgendre+L%22">Aupetitgendre L</searchLink>; Department of Anesthesia and Intensive Care, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Bhathal+IR%22">Bhathal IR</searchLink>; Servei d'Anestesiologia i Reanimació, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Álvarez+RG%22">Álvarez RG</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bernard+A%22">Bernard A</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenberger+P%22">Rosenberger P</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wempe+C%22">Wempe C</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Sadjadi+M%22">Sadjadi M</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Meersch+M%22">Meersch M</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Fischhuber+K%22">Fischhuber K</searchLink>; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kellum+JA%22">Kellum JA</searchLink>; Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22von+Groote+T%22">von Groote T</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
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