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Exosomal Pparα derived from cancer cells induces CD8 + T cell exhaustion in hepatocellular carcinoma through the miR-27b-3p /TOX axis.

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Title: Exosomal Pparα derived from cancer cells induces CD8 + T cell exhaustion in hepatocellular carcinoma through the miR-27b-3p /TOX axis.
Authors: Zhong W; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China., Luo N; Department of General Surgery, 943 Hospital of PLA, Wuwei, Gansu 733000, China., Chen Y; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China., Li J; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China., Yang Z; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China., Dong R; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
Source: Chinese medical journal [Chin Med J (Engl)] 2025 Dec 05; Vol. 138 (23), pp. 3139-3152. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article
Journal Info: Publisher: Chinese Medical Association ; produced by Wolters Kluwer Country of Publication: China NLM ID: 7513795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-5641 (Electronic) Linking ISSN: 03666999 NLM ISO Abbreviation: Chin Med J (Engl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosomal Pparα derived from cancer cells induces CD8 + T cell exhaustion in hepatocellular carcinoma through the miR-27b-3p /TOX axis.
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  Data: <searchLink fieldCode="AU" term="%22Zhong+W%22">Zhong W</searchLink>; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.<br /><searchLink fieldCode="AU" term="%22Luo+N%22">Luo N</searchLink>; Department of General Surgery, 943 Hospital of PLA, Wuwei, Gansu 733000, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.<br /><searchLink fieldCode="AU" term="%22Dong+R%22">Dong R</searchLink>; Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
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  Data: <searchLink fieldCode="JN" term="%227513795%22">Chinese medical journal</searchLink> [Chin Med J (Engl)] 2025 Dec 05; Vol. 138 (23), pp. 3139-3152. <i>Date of Electronic Publication: </i>2025 Nov 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Chinese+Medical+Association+%3B+produced+by+Wolters+Kluwer%22">Chinese Medical Association ; produced by Wolters Kluwer </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>7513795 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2542-5641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203666999%22">03666999 </searchLink><i>NLM ISO Abbreviation: </i>Chin Med J (Engl) <i>Subsets: </i>MEDLINE
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        Value: 10.1097/CM9.0000000000003894
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      – Code: eng
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      – TitleFull: Exosomal Pparα derived from cancer cells induces CD8 + T cell exhaustion in hepatocellular carcinoma through the miR-27b-3p /TOX axis.
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              Text: 2025 Dec 05
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