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Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS): a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial.

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Title: Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS): a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial.
Authors: Raj R; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. rahul.raj@hus.fi., Tommiska P; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Kivisaari R; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Korja M; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Luostarinen T; Anesthesiology and Intensive Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Virta JJ; Anesthesiology and Intensive Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Taimela S; Finnish Centre for Evidence-Based Orthopedics (FICEBO), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Järvinen TLN; Finnish Centre for Evidence-Based Orthopedics (FICEBO), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Niemelä M; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Koivisto T; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland., Leinonen V; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland., Saemundsson B; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden., Fletcher-Sandersjöö A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden., Korhonen T; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland., Tetri S; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland., Rauhala M; Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland., Laukka D; Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland., Czuba T; Department of Molecular and Clinical Medicine/The Wallenberg Laboratory, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden., Bartek J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden., Danner N; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland., Knuutinen O; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland., Luoto T; Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland., Posti JP; Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Neurosurgery, University of Turku, Turku, Finland., Satopää J; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Source: Trials [Trials] 2025 Nov 17; Vol. 26 (1), pp. 515. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Restarting anticoagulation early versus late in patients with chronic subdural hematoma and atrial fibrillation (RELACS): a phase III international multicenter, randomized controlled, two-arm, assessor-blinded trial.
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  Data: <searchLink fieldCode="AU" term="%22Raj+R%22">Raj R</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. rahul.raj@hus.fi.<br /><searchLink fieldCode="AU" term="%22Tommiska+P%22">Tommiska P</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Kivisaari+R%22">Kivisaari R</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Korja+M%22">Korja M</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Luostarinen+T%22">Luostarinen T</searchLink>; Anesthesiology and Intensive Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Virta+JJ%22">Virta JJ</searchLink>; Anesthesiology and Intensive Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Taimela+S%22">Taimela S</searchLink>; Finnish Centre for Evidence-Based Orthopedics (FICEBO), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Järvinen+TLN%22">Järvinen TLN</searchLink>; Finnish Centre for Evidence-Based Orthopedics (FICEBO), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Niemelä+M%22">Niemelä M</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Koivisto+T%22">Koivisto T</searchLink>; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Leinonen+V%22">Leinonen V</searchLink>; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Saemundsson+B%22">Saemundsson B</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Fletcher-Sandersjöö+A%22">Fletcher-Sandersjöö A</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Korhonen+T%22">Korhonen T</searchLink>; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Tetri+S%22">Tetri S</searchLink>; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Rauhala+M%22">Rauhala M</searchLink>; Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Laukka+D%22">Laukka D</searchLink>; Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Czuba+T%22">Czuba T</searchLink>; Department of Molecular and Clinical Medicine/The Wallenberg Laboratory, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Bartek+J%22">Bartek J</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Danner+N%22">Danner N</searchLink>; Department of Neurosurgery, Kuopio University Hospitaland, University of Eastern Finland , Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Knuutinen+O%22">Knuutinen O</searchLink>; University of Oulu and Medical Research Center, Unit of Clinical Neuroscience, Neurosurgery, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Luoto+T%22">Luoto T</searchLink>; Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Posti+JP%22">Posti JP</searchLink>; Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Neurosurgery, University of Turku, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Satopää+J%22">Satopää J</searchLink>; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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