CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial.
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| Title: | CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial. |
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| Authors: | Knoll RL; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Brauny MM; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Robert E; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Cloos L; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Waser L; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Hilbert K; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Ulmer N; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Hillen B; Department of Sports Medicine, Prevention, and Rehabilitation, Institute of Sports Science, Johannes Gutenberg‑University Mainz, Mainz, Germany., Birkner T; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany., Bartolomaeus TUP; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany., Nitsche O; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Jarquín-Díaz VH; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany., Lynch S; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Gehring S; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Maier L; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Poplawska K; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany. krpoplawska@icloud.com., Forslund-Startceva SK; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Structural and Computational Biology Unit, EMBL, Heidelberg, Germany. sofia.forslund@mdc-berlin.de. |
| Source: | Nature communications [Nat Commun] 2025 Nov 18; Vol. 16 (1), pp. 10111. Date of Electronic Publication: 2025 Nov 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64218-z |
