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CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial.

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Title: CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial.
Authors: Knoll RL; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Brauny MM; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Robert E; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Cloos L; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Waser L; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Hilbert K; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Ulmer N; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Hillen B; Department of Sports Medicine, Prevention, and Rehabilitation, Institute of Sports Science, Johannes Gutenberg‑University Mainz, Mainz, Germany., Birkner T; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany., Bartolomaeus TUP; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany., Nitsche O; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Jarquín-Díaz VH; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany., Lynch S; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Gehring S; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany., Maier L; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany., Poplawska K; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany. krpoplawska@icloud.com., Forslund-Startceva SK; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Structural and Computational Biology Unit, EMBL, Heidelberg, Germany. sofia.forslund@mdc-berlin.de.
Source: Nature communications [Nat Commun] 2025 Nov 18; Vol. 16 (1), pp. 10111. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial.
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  Data: <searchLink fieldCode="AU" term="%22Knoll+RL%22">Knoll RL</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brauny+MM%22">Brauny MM</searchLink>; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Robert+E%22">Robert E</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Cloos+L%22">Cloos L</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Waser+L%22">Waser L</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Hilbert+K%22">Hilbert K</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Ulmer+N%22">Ulmer N</searchLink>; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hillen+B%22">Hillen B</searchLink>; Department of Sports Medicine, Prevention, and Rehabilitation, Institute of Sports Science, Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Birkner+T%22">Birkner T</searchLink>; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bartolomaeus+TUP%22">Bartolomaeus TUP</searchLink>; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nitsche+O%22">Nitsche O</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Jarquín-Díaz+VH%22">Jarquín-Díaz VH</searchLink>; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lynch+S%22">Lynch S</searchLink>; Division of Gastroenterology and Benioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gehring+S%22">Gehring S</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Maier+L%22">Maier L</searchLink>; Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, Tübingen, Germany.; M3 Research Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Poplawska+K%22">Poplawska K</searchLink>; Children's Hospital, University Medical Center of the Johannes Gutenberg‑University Mainz, Mainz, Germany. krpoplawska@icloud.com.<br /><searchLink fieldCode="AU" term="%22Forslund-Startceva+SK%22">Forslund-Startceva SK</searchLink>; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de.; DZHK (German Centre for Cardiovascular Research), Berlin, Germany. sofia.forslund@mdc-berlin.de.; Structural and Computational Biology Unit, EMBL, Heidelberg, Germany. sofia.forslund@mdc-berlin.de.
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