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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.

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Bibliographic Details
Title: Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.
Authors: Sparling BA; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lee H; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Zablocki MM; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lynes MM; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Grigoriu S; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Shehaj L; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lockbaum GJ; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Khan SK; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Hotz T; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lee YT; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Buker SM; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Gotur D; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lu C; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Ribich S; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Blakemore SJ; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Boriack-Sjodin PA; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Silver SJ; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Copeland RA; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Duncan KW; Accent Therapeutics, 1050 Waltham Street, Lexington, Massachusetts 02421, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 Oct 27; Vol. 16 (11), pp. 2309-2319. Date of Electronic Publication: 2025 Oct 27 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.5c00512