Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing.
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| Title: | Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing. |
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| Authors: | Wu KJ; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Li JC; Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, 6 Shuang yong RD, Nanning, 530021, China., Liu LM; Department of Toxicology, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Huang XJ; Department of Toxicology, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China.; Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Mo LH; Department of Toxicology, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China.; Pharmacy Department of Rui Kang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Ling JW; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Xiong KH; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Zhang W; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., He RQ; Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China., Li H; Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China. lihui_gxmu@163.com., Chen G; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China. chengang@gxmu.edu.cn. |
| Source: | BMC gastroenterology [BMC Gastroenterol] 2025 Nov 19; Vol. 25 (1), pp. 818. Date of Electronic Publication: 2025 Nov 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1471-230X |
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| DOI: | 10.1186/s12876-025-04423-8 |
