Pancreastatin inhibitor PSTi8 alleviates insulin resistance and ovarian dysfunction in a dehydroepiandrosterone-high-fat diet rat model of polycystic ovary syndrome.

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Title: Pancreastatin inhibitor PSTi8 alleviates insulin resistance and ovarian dysfunction in a dehydroepiandrosterone-high-fat diet rat model of polycystic ovary syndrome.
Authors: Yadav S; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Dadge S; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Rathaur S; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India., Maity D; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Prajapati VM; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India; Division of Toxicological & Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, India., Gayen JR; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. Electronic address: jr.gayen@cdri.res.in.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Dec; Vol. 392 (12), pp. 103765. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-0103
DOI:10.1016/j.jpet.2025.103765