Pre-existing CD95-based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD-L1 and TGFβ inhibition.
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| Title: | Pre-existing CD95-based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD-L1 and TGFβ inhibition. |
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| Authors: | Kam NW; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Lau JYH; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lau CY; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Lam TC; Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Chan KSK; LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Dai W; Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Fun VLH; Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China., Chiang CL; Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China., Kwong DLW; Department of Clinical Oncology, Centre of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Clinical Oncology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. |
| Source: | Clinical and translational medicine [Clin Transl Med] 2025 Nov; Vol. 15 (11), pp. e70535. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2001-1326 |
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| DOI: | 10.1002/ctm2.70535 |
