Endothelial protein C receptor-mediated endogenous and therapeutic transport of activated protein C across the blood-retina barrier protects the retina.

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Title: Endothelial protein C receptor-mediated endogenous and therapeutic transport of activated protein C across the blood-retina barrier protects the retina.
Authors: Livnat T; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; National Hemophilia Center, Thrombosis and Hemostasis Institute, Sheba Medical Center, Ramat Gan, Israel; Rabin Medical Center, Ophthalmology Department and Laboratory of Eye Research, Felsenstein Medical Research Center, Petah Tikva, Israel; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Budnik I; Department of Internal Medicine, Division of Hematology, Oncology, and Blood and Marrow Transplantation, The University of Iowa, Iowa City, Iowa, USA., Nisgav Y; Rabin Medical Center, Ophthalmology Department and Laboratory of Eye Research, Felsenstein Medical Research Center, Petah Tikva, Israel., Dardik R; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; National Hemophilia Center, Thrombosis and Hemostasis Institute, Sheba Medical Center, Ramat Gan, Israel., Avishai E; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; National Hemophilia Center, Thrombosis and Hemostasis Institute, Sheba Medical Center, Ramat Gan, Israel., Gonen SR; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Zahavi A; Rabin Medical Center, Ophthalmology Department and Laboratory of Eye Research, Felsenstein Medical Research Center, Petah Tikva, Israel; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Fernández JA; Department of Translational Medicine, The Scripps Research Institute, La Jolla, California, USA., Golderman V; Department of Neurology and Neurosurgery, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Sheba Medical Center, Ramat Gan, Israel., Goldberg Z; Department of Neurology and Neurosurgery, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Sheba Medical Center, Ramat Gan, Israel., Kenet G; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; National Hemophilia Center, Thrombosis and Hemostasis Institute, Sheba Medical Center, Ramat Gan, Israel., Griffin JH; Department of Translational Medicine, The Scripps Research Institute, La Jolla, California, USA., Levy-Mendelovich S; The Amalia Biron Research Institute of Thrombosis and Hemostasis, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; National Hemophilia Center, Thrombosis and Hemostasis Institute, Sheba Medical Center, Ramat Gan, Israel; Talpiot Medical Leadership Program, Sheba Medical Center, Ramat Gan, Israel. Electronic address: levysarina@gmail.com.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 Mar; Vol. 24 (3), pp. 1141-1152. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7836
DOI:10.1016/j.jtha.2025.10.033