Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.

Saved in:
Bibliographic Details
Title: Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.
Authors: Caro I; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France., Western D; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Namba S; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Suita, Japan., Sun N; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kawaguchi S; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., He Y; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Fujita M; Department of Neurology, Center for Translational and Computational Neuroimmunology, Columbia University Irving Medical Center, New York, NY, USA., Roshchupkin G; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands., D'Aoust T; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France., Duperron MG; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France.; Department of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, France., Sargurupremraj M; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Tsuchida A; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France.; Institut des Maladies Neurodégénératives, IMN-UMR5293, Université de Bordeaux, CNRS, CEA, Bordeaux, France., Koido M; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Ahmadi M; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Quebec, Canada., Yang C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Timsina J; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Matsuda K; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Suzuki Y; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Oda Y; Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kanai A; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Jandaghi P; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Quebec, Canada., Munter M; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Quebec, Canada., Auld D; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Quebec, Canada., Astafeva I; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France.; Institut des Maladies Neurodégénératives, IMN-UMR5293, Université de Bordeaux, CNRS, CEA, Bordeaux, France., Puerta R; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Couffinhal T; Inserm U1034, Biologie Des Maladies Cardiovasculaires, Université de Bordeaux, Bordeaux, France., García-González P; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Pytel V; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Cano A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Joliot M; Institut des Maladies Neurodégénératives, IMN-UMR5293, Université de Bordeaux, CNRS, CEA, Bordeaux, France., Lathrop M; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Quebec, Canada., Le Grand Q; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France.; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Launer LJ; Intramural Research Program, National Institue on Aging, Baltimore, MD, USA., Wardlaw JM; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, Edinburgh, UK.; UK Dementia Research Institute Centre at the University of Edinburgh and Centre for Vascular Dementia Research, Edinburgh, UK., Heiman M; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Ruiz A; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Matthews PM; Department of Brain Sciences, Imperial College, London, UK.; UK Dementia Research Institute Centre at Imperial, Imperial College, London, UK., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Adams H; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Mishra A; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France., Trégouët DA; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France., Okada Y; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., De Jager PL; Department of Neurology, Center for Translational and Computational Neuroimmunology, Columbia University Irving Medical Center, New York, NY, USA., Tzourio C; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France., Kamatani Y; Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. cruchagac@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA. cruchagac@wustl.edu., Debette S; Bordeaux Population Health Research Center, Inserm U1219, Université de Bordeaux, Bordeaux, France. stephanie.debette@inserm.fr.; Department of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, France. stephanie.debette@inserm.fr.; Institut du Cerveau (ICM), Paris Brain Institute, INSERM U1127, UMR CNRS 7225 Paris, Sorbonne Université, Assistance Publique des Hôpitaux de Paris, Paris, France. stephanie.debette@inserm.fr.
Source: Nature aging [Nat Aging] 2025 Dec; Vol. 5 (12), pp. 2514-2531. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-025-01006-w