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Clinical significance of non-invasive in vitro drug sensitivity profiling using pancreatic cancer organoids derived from saline flushes collected during routine EUS-FNA.

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Title: Clinical significance of non-invasive in vitro drug sensitivity profiling using pancreatic cancer organoids derived from saline flushes collected during routine EUS-FNA.
Authors: Ekawa T; Department of Cancer Drug Discovery and Development, Research Centre, Osaka International Cancer Institute, Osaka, Japan. tomoya.ekawa@oici.jp.; Department of Cancer Immunotherapy, Research Centre, Osaka International Cancer Institute, Osaka, Japan. tomoya.ekawa@oici.jp., Ikezawa K; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Kukita Y; Laboratory of Genomic Pathology, Research Centre, Osaka International Cancer Institute, Osaka, Japan., Urabe M; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Kai Y; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Takada R; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Akazawa T; Department of Cancer Drug Discovery and Development, Research Centre, Osaka International Cancer Institute, Osaka, Japan.; Department of Cancer Immunotherapy, Research Centre, Osaka International Cancer Institute, Osaka, Japan., Mizote Y; Department of Cancer Drug Discovery and Development, Research Centre, Osaka International Cancer Institute, Osaka, Japan.; Department of Cancer Immunotherapy, Research Centre, Osaka International Cancer Institute, Osaka, Japan., Tatsumi K; Department of Cancer Drug Discovery and Development, Research Centre, Osaka International Cancer Institute, Osaka, Japan.; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Medical Development, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan., Nagata S; Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan., Ogawa H; Nitto Joint Research Department for Nucleic Acid Medicine, Research Centre, Osaka International Cancer Institute, Osaka, Japan., Hasegawa S; Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan., Takahashi H; Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan., Ohkawa K; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Tahara H; Department of Cancer Drug Discovery and Development, Research Centre, Osaka International Cancer Institute, Osaka, Japan.; Centre for Clinical Research, Osaka International Cancer Institute, Osaka, Japan.
Source: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2026 May; Vol. 28 (5), pp. 1940-1946. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Italia Country of Publication: Italy NLM ID: 101247119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-3055 (Electronic) Linking ISSN: 1699048X NLM ISO Abbreviation: Clin Transl Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1699-3055
DOI:10.1007/s12094-025-04111-9