Spermine modulation of Alzheimer's Tau and Parkinson's α-synuclein: implications for biomolecular condensation and neurodegeneration.

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Title: Spermine modulation of Alzheimer's Tau and Parkinson's α-synuclein: implications for biomolecular condensation and neurodegeneration.
Authors: Sun X; Center for Life Sciences, Paul Scherrer Institute, Villigen, PSI, Switzerland., Saha D; College of Integrative Sciences and Arts, Arizona State University, Mesa, AZ, USA., Wang X; Center for Life Sciences, Paul Scherrer Institute, Villigen, PSI, Switzerland., Mörman C; Center for Life Sciences, Paul Scherrer Institute, Villigen, PSI, Switzerland.; Department of Medicine Huddinge, Division of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Sternke-Hoffmann R; Center for Life Sciences, Paul Scherrer Institute, Villigen, PSI, Switzerland., Gerez JA; Institute of Molecular Physical Science, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Herranz-Trillo F; CoSAXS Beamline, MAX IV Laboratory, Lund, Sweden., Riek R; Institute of Molecular Physical Science, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Zheng W; College of Integrative Sciences and Arts, Arizona State University, Mesa, AZ, USA., Luo J; Center for Life Sciences, Paul Scherrer Institute, Villigen, PSI, Switzerland. jinghui.luo@psi.ch.
Source: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10239. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-65426-3