Cell passage number drives transcriptomic drift as an overlooked factor in experimental reproducibility.
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| Title: | Cell passage number drives transcriptomic drift as an overlooked factor in experimental reproducibility. |
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| Authors: | Liu S; Department of Laboratory, The Fourth People's Hospital of Shenzhen (Shenzhen Samii Medical Center), Shenzhen, 518118, Guangdong, China., Peng H; Department of Critical Care Medicine, Longgang Central Hospital (Shenzhen Clinical College, Guangzhou University of Chinese Medicine), Shenzhen 6082 Longgang Road, Shenzhen, 518116, Guangdong, China., Meng J; Department of Critical Care Medicine, Longgang Central Hospital (Shenzhen Clinical College, Guangzhou University of Chinese Medicine), Shenzhen 6082 Longgang Road, Shenzhen, 518116, Guangdong, China., Zhuo L; Department of Critical Care Medicine, Longgang Central Hospital (Shenzhen Clinical College, Guangzhou University of Chinese Medicine), Shenzhen 6082 Longgang Road, Shenzhen, 518116, Guangdong, China., Fu S; Department of Critical Care Medicine, Longgang Central Hospital (Shenzhen Clinical College, Guangzhou University of Chinese Medicine), Shenzhen 6082 Longgang Road, Shenzhen, 518116, Guangdong, China. fushaoping1983@126.com., Yang W; Department of Critical Care Medicine, Longgang Central Hospital (Shenzhen Clinical College, Guangzhou University of Chinese Medicine), Shenzhen 6082 Longgang Road, Shenzhen, 518116, Guangdong, China. yangw6@mail2.sysu.edu.cn. |
| Source: | Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 44984. Date of Electronic Publication: 2025 Nov 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-29424-1 |
