A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility.

Saved in:
Bibliographic Details
Title: A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility.
Authors: Min SC; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Seo JJ; Technological Convergence Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea., Jeong JH; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.; Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Republic of Korea., Kim BK; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.; Microuni, Co. Ltd., Cheongju, Chungbuk, Republic of Korea., Park JH; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Lee JR; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Lee DG; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Lee GC; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea.; Microuni, Co. Ltd., Cheongju, Chungbuk, Republic of Korea., An SH; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Baek YH; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea., Choi YK; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Choo H; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Divison of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of Korea., Park HY; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea., Kim G; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea., Jeon B; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; Divison of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, Republic of Korea., Shin SC; Technological Convergence Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea. scshin84@kist.re.kr., Song MS; Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, Republic of Korea. songminsuk@chungbuk.ac.kr.; Microuni, Co. Ltd., Cheongju, Chungbuk, Republic of Korea. songminsuk@chungbuk.ac.kr.; Chungbuk National University Hospital, Chungdae-ro 1, Seowon-gu, Cheongju, Republic of Korea. songminsuk@chungbuk.ac.kr.
Source: Nature communications [Nat Commun] 2025 Nov 22; Vol. 16 (1), pp. 10737. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-65767-z