PufA drives cholangiocarcinoma progression via NFκB signaling activation: a novel therapeutic target.

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Title: PufA drives cholangiocarcinoma progression via NFκB signaling activation: a novel therapeutic target.
Authors: Chen CP; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Hung TH; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC., Huang Y; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC.; School of medicine, National Tsing Hua University, Hsinchu, Taiwan, ROC.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC., Pan YR; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of General Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC., Yeh CN; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of General Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC., Huang WK; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Hsiao YT; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Lo CH; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Yu AL; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC., Yu J; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC. johnyu@gate.sinica.edu.tw., Wu CE; Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. 8805017@cgmh.org.tw.; College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC. 8805017@cgmh.org.tw.; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. 8805017@cgmh.org.tw.; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ROC. 8805017@cgmh.org.tw.; Division of Hematology-Oncology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan, ROC. 8805017@cgmh.org.tw.
Source: Cancer gene therapy [Cancer Gene Ther] 2026 Jan; Vol. 33 (1), pp. 132-144. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5500 (Electronic) Linking ISSN: 09291903 NLM ISO Abbreviation: Cancer Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5500
DOI:10.1038/s41417-025-00968-8