The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty.

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Title: The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty.
Authors: Leana-Sandoval G; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA, 92697, USA.; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA., Madrid A; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA, 92697, USA.; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA., Kolli AV; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA, 92697, USA.; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA., Chinn CA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA.; Department of Neurobiology & Behavior, University of California at Irvine, Irvine, CA, 92697, USA., Sandoval MA; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA, 92697, USA.; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA., Lo I; Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA., Alizo Vera V; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA.; Department of Neurobiology & Behavior, University of California at Irvine, Irvine, CA, 92697, USA., Simms J; Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA., Wood MA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA.; Department of Neurobiology & Behavior, University of California at Irvine, Irvine, CA, 92697, USA., Díaz-Alonso J; Department of Anatomy & Neurobiology, University of California at Irvine, Irvine, CA, 92697, USA. jdiazalo@uci.edu.; Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, 92697, USA. jdiazalo@uci.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 2119-2132. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03328-y