Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer.

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Title: Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer.
Authors: Iwane K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakanishi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. yuki@kuhp.kyoto-u.ac.jp., Muta Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. yumuta@kuhp.kyoto-u.ac.jp., Chen J; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yasumura K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Omatsu M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Aoyama N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ikeda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Masui Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Cai L; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yamakawa G; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hamada K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mizukoshi K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kawai M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Iimori K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakayama S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Agatsuma N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Utsumi T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nagao M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hiramatsu Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kakiuchi N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Nakagawa MM; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Fukui Y; Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate Scholl of Medicine, Osaka, Japan., Kusunoki Y; Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate Scholl of Medicine, Osaka, Japan., Kasashima H; Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate Scholl of Medicine, Osaka, Japan., Fujimoto M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan., Itatani Y; Department of Gastrointestinal Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kogame T; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Fukuda A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yashiro M; Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate Scholl of Medicine, Osaka, Japan., Maeda K; Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate Scholl of Medicine, Osaka, Japan., Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Obama K; Department of Gastrointestinal Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan., Diaz-Meco MT; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Moscat J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, USA., Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Source: Nature communications [Nat Commun] 2025 Nov 23; Vol. 16 (1), pp. 11590. Date of Electronic Publication: 2025 Nov 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-66485-2