Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors.

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Title: Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors.
Authors: Ko FH; Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA., Lukens AK; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA USA., de Souza ML; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA., Foy A; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA., Hsiao J; Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA., Ndiaye T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Park H; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Uhlemann AC; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Boonyalai N; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Kumpornsin K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire UK., Girling G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire UK., Pasaje C; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA., Godoy L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA., Ottilie S; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA., Durst GL; Lgenia Inc., Fortville, IN 46040, USA., Chatterjee A; Scripps Research Institute, La Jolla, CA 92037, USA., Niles J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA., Lee M; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire UK., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Wirth DF; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA USA., Winzeler EA; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 01. Date of Electronic Publication: 2025 Nov 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.10.30.684657