Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.

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Title: Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.
Authors: Thorpe HHA; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Cupertino RB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Pakala SR; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Fontanillas P; 23andMe, Inc., Sunnyvale, CA, USA., Jennings MV; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Yang J; Department of Pharmacology, University of California San Diego, La Jolla, CA, USA., Meredith JJ; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Greenwood T; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Bianchi SB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Vilar-Ribó L; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Niarchou M; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Elson SL; 23andMe, Inc., Sunnyvale, CA, USA., Ideker T; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Davis LK; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Associate Faculty, New York Genome Center, New York, NY, USA., MacKillop J; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.; Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Michael G DeGroote Centre for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada., deWit H; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Gustavson DE; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Mallard TT; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. sanchezroige@ucsd.edu.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. sanchezroige@ucsd.edu.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. sanchezroige@ucsd.edu.
Corporate Authors: 23andMe Research Team
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 2081-2093. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03356-8