Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease.
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| Title: | Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease. |
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| Authors: | Wang L; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Xie XY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Pan QL; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang J; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Zhou GF; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang QL; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China., Yan XX; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China., Xiang Y; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Li CL; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., He Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Xiang XJ; Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Deng XJ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China., Zhou JY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Nie S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Chen GJ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn. |
| Source: | Nature communications [Nat Commun] 2025 Nov 26; Vol. 16 (1), pp. 10514. Date of Electronic Publication: 2025 Nov 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65547-9 |
