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Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease.

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Title: Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease.
Authors: Wang L; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Xie XY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Pan QL; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang J; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Zhou GF; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang QL; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China., Yan XX; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China., Xiang Y; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Li CL; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., He Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Xiang XJ; Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Deng XJ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China., Zhou JY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Nie S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China., Chen GJ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Nov 26; Vol. 16 (1), pp. 10514. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Xie+XY%22">Xie XY</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Pan+QL%22">Pan QL</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GF%22">Zhou GF</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+QL%22">Zhang QL</searchLink>; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China.<br /><searchLink fieldCode="AU" term="%22Yan+XX%22">Yan XX</searchLink>; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China.<br /><searchLink fieldCode="AU" term="%22Xiang+Y%22">Xiang Y</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+CL%22">Li CL</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; 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Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+JY%22">Zhou JY</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Nie+S%22">Nie S</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), College of Pharmacy, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+GJ%22">Chen GJ</searchLink>; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Major Neurological and Mental Disorders, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Chongqing Key Laboratory of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Neurology Key Laboratory of Chongqing Education Commission of China, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 203165@cqmu.edu.cn.
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