Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas.

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Title: Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas.
Authors: Hinz FE; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Friedel D; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Bioscience, Heidelberg University, Heidelberg, Germany., Ippen FM; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; A Partnership Between DKFZ and University Hospital Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, Heidelberg, Germany.; Department of Neurology and European Center for Neurooncology (EZN), University Hospital Heidelberg, Heidelberg, Germany., Sill M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Korshunov A; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Schweizer L; Neurological Institute (Edinger Institute), Goethe University, Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt, German Cancer Research Center (DKFZ), Frankfurt, Germany.; University Cancer Center, Goethe University Frankfurt, Frankfurt, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt, Germany., Schrimpf D; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Göbel K; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Friedrich LS; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Aras FK; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Bogumil H; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pathology Nordhessen, Kassel, Germany., Banan R; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Dohmen H; Institute of Neuropathology, Justus-Liebig University Giessen, Giessen, Germany., Acker T; Institute of Neuropathology, Justus-Liebig University Giessen, Giessen, Germany., Brandner S; Institute of Neurology, University College London, London, UK., Schmid S; Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Capper D; Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Grassl N; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Boldt HB; Department of Pathology, Odense University Hospital, Odense, Denmark., Wesseling P; Department of Pathology, Amsterdam University Medical Centers, Amsterdam and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Maas SLN; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Martinez JPG; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany., Stadelmann C; Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany., Reifenberger G; Institute of Neuropathology, Partner Site Essen/Düsseldorf, Medical Faculty, and University Hospital Düsseldorf, German Cancer Consortium (DKTK), Heinrich Heine University, Düsseldorf, Germany., Stehle T; Institute for Neuropathology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Barrantes-Freer A; University of Leipzig Medical Center, Paul-Flechsig-Institute of Neuropathology, Leipzig, Germany., Juratli TA; Department for Neurosurgery, TU Dresden University of Technology, Dresden, Germany., Pusch S; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Haag D; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany., Reuss DE; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Herold-Mende C; Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Krieg S; Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Wick W; A Partnership Between DKFZ and University Hospital Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, Heidelberg, Germany.; Department of Neurology and European Center for Neurooncology (EZN), University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Etminan N; Department of Neurosurgery, Heidelberg University, Mannheim, Germany., Platten M; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Mannheim, Germany.; DKFZ-Hector Cancer Institute at University Medical Center Mannheim, Mannheim, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Jones DTW; A Partnership Between DKFZ and University Hospital Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sahm F; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., von Deimling A; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Suwala AK; Department of Neuropathology, Pathological Institute, Heidelberg University Hospital, Heidelberg, Germany. Abigail.Suwala@med.uni-heidelberg.de.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Abigail.Suwala@med.uni-heidelberg.de.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Nov 26; Vol. 150 (1), pp. 56. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Letter
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-025-02963-7