Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.
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| Title: | Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD. |
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| Authors: | Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kang S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Lee YJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Oh S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Joo B; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Hwang JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kim J; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Pharmacology, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea., Kim TE; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jung TM; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kim YJ; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jang JY; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Song JH; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Koo JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Hoe HS; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Nov 11; Vol. 16, pp. 1661791. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1661791 |
