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Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.

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Title: Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.
Authors: Lee HJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kang S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Lee YJ; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Oh S; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Joo B; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Hwang JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kim J; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Pharmacology, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea., Kim TE; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jung TM; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Kim YJ; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Jang JY; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Song JH; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Koo JW; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea., Hoe HS; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.
Source: Frontiers in immunology [Front Immunol] 2025 Nov 11; Vol. 16, pp. 1661791. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.
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  Data: <searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+S%22">Kang S</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YJ%22">Lee YJ</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Joo+B%22">Joo B</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hwang+JW%22">Hwang JW</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Pharmacology, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+TE%22">Kim TE</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+TM%22">Jung TM</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+JY%22">Jang JY</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+JH%22">Song JH</searchLink>; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Koo+JW%22">Koo JW</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hoe+HS%22">Hoe HS</searchLink>; Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; AI-based Neurodevelopmental Diseases Digital Therapeutics Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Nov 11; Vol. 16, pp. 1661791. <i>Date of Electronic Publication: </i>2025 Nov 11 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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