The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ.

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Title: The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ.
Authors: Martin PR; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK. peter.martin@icr.ac.uk., Nieminuszczy J; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Kozik Z; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Jakub N; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Kowalski S; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.; Department of Pharmacology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland., Lecot M; Faculty of Medicine of Rennes, University of Rennes, Rennes, France., Vorhauser J; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Lane KA; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Kanellou A; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Mansfeld J; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Pearl LH; Division of Structural Biology, The Institute of Cancer Research, London, UK.; Genome Damage and Stability Centre, University of Sussex, Brighton, UK., Oliver AW; Genome Damage and Stability Centre, University of Sussex, Brighton, UK., Downs JA; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Choudhary JS; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Day M; Division of Structural Biology, The Institute of Cancer Research, London, UK.; Centre of Molecular Cell Biology, Queen Mary University of London, London, UK., Niedzwiedz W; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK. wojciech.niedzwiedz@icr.ac.uk.
Source: Nature communications [Nat Commun] 2025 Nov 27; Vol. 16 (1), pp. 10623. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-65594-2