Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria.

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Title: Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria.
Authors: Eli S; IEO, European Institute of Oncology IRCCS, Milan, Italy.; AMOLF Institute, Amsterdam, The Netherlands., Rauso G; IEO, European Institute of Oncology IRCCS, Milan, Italy., Ghezzi P; IEO, European Institute of Oncology IRCCS, Milan, Italy., Szczerkowski JLA; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Bruzzi M; IEO, European Institute of Oncology IRCCS, Milan, Italy., Rizzelli F; IEO, European Institute of Oncology IRCCS, Milan, Italy., Iommazzo F; IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Health Sciences, University of Milan, Milan, Italy., Loffreda A; IRCCS Ospedale San Raffaele, Experimental Imaging Center, Milan, Italy., Castagna F; IEO, European Institute of Oncology IRCCS, Milan, Italy., Donà F; IEO, European Institute of Oncology IRCCS, Milan, Italy., Gaddoni C; IEO, European Institute of Oncology IRCCS, Milan, Italy., Dondi A; IEO, European Institute of Oncology IRCCS, Milan, Italy., Marenda M; IEO, European Institute of Oncology IRCCS, Milan, Italy., Rodighiero S; IEO, European Institute of Oncology IRCCS, Milan, Italy., Tournier P; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Lavagnino Z; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Parazzoli D; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Gauthier NC; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Tamburri S; IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Health Sciences, University of Milan, Milan, Italy., Pasini D; IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Health Sciences, University of Milan, Milan, Italy., Habib SJ; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. ShukryJames.habib@unil.ch., Mapelli M; IEO, European Institute of Oncology IRCCS, Milan, Italy. marina.mapelli@ieo.it.
Source: Nature communications [Nat Commun] 2025 Nov 27; Vol. 16 (1), pp. 10690. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-65775-z