Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.

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Title: Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.
Authors: Musicha P; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Beale MA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Cocker D; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Oruru FA; Infectious Disease Institute, Makerere University, Kampala, Uganda., Zuza A; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Salifu C; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Katende G; Infectious Disease Institute, Makerere University, Kampala, Uganda., Nanono S; Infectious Disease Institute, Makerere University, Kampala, Uganda., Isaasi F; Infectious Disease Institute, Makerere University, Kampala, Uganda., Chidziwisano K; Malawi University of Business and Applied Sciences, Blantyre, Malawi., Mugisha L; College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Kajumbula H; College of Health Sciences, Makerere University, Kampala, Uganda., Musoke D; School of Public Health, Makerere University, Kampala, Uganda., Morse T; Department of Civil and Environmental Engineering, University of Strathclyde, Glasgow, UK., Jacob ST; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Walimu, Kampala, Uganda., Feasey NA; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; School of Medicine, University of St Andrews, St Andrews, UK., Thomson NR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: pm13@sanger.ac.uk.
Source: The Lancet. Microbe [Lancet Microbe] 2026 Jan; Vol. 7 (1), pp. 101224. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2666-5247
DOI:10.1016/j.lanmic.2025.101224