Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome.
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| Title: | Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome. |
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| Authors: | Oshima M; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Takayama N; Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan., Nakajima-Takagi Y; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Shinoda D; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Itokawa N; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kurosawa S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kaito S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kamiya T; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Yamada Y; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Andoh S; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kayamori K; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Hematology, Chiba University Hospital, Chiba, Japan., Paul SK; Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan., Kanashiro MA; Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan., Muto T; Department of Hematology, Chiba University Hospital, Chiba, Japan., Tsukamoto S; Department of Hematology, Chiba University Hospital, Chiba, Japan., Sakaida E; Department of Hematology, Chiba University Hospital, Chiba, Japan., Sato E; Department of Hematology, Juntendo University Nerima Hospital, Tokyo, Japan., Yusa N; Department of Hematology and Oncology, Research Hospital, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Yokoyama K; Department of Hematology and Oncology, Research Hospital, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Nannya Y; Department of Hematology and Oncology, Research Hospital, The Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Imoto S; Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Rahmutulla B; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kaneda A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Health and Disease Omics Center, Chiba University, Chiba, Japan., Yamaguchi K; Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Furukawa Y; Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Doki N; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Eto K; Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan., Nishikawa K; Department of Oncology and Hematology, Edogawa Hospital, Tokyo, Japan., Ding Y; Department of Oncology and Hematology, Edogawa Hospital, Tokyo, Japan., Myojo T; Department of Oncology and Hematology, Edogawa Hospital, Tokyo, Japan., Harada Y; Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Harada H; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Iwama A; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. 03aiwama@ims.u-tokyo.ac.jp.; Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. 03aiwama@ims.u-tokyo.ac.jp. |
| Source: | Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10726. Date of Electronic Publication: 2025 Nov 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65753-5 |
