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Screening of one-bead one-compound cyclic peptide libraries using unpurified proteins from the wheat germ cell-free system to identify protein-protein interaction inhibitors.

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Title: Screening of one-bead one-compound cyclic peptide libraries using unpurified proteins from the wheat germ cell-free system to identify protein-protein interaction inhibitors.
Authors: Hasegawa M; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan; Division of Cell-Free Life Science, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan. Electronic address: hasegawa.miki@ma.mt-pharma.co.jp., Nozawa A; Division of Cell-Free Life Science, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan., Tanaka Y; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Kido K; Division of Cell-Free Life Science, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan., Terawaki S; Division of Structure Analysis of Protein Complex, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan., Takahashi C; Division of Cell-Free Life Science, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan., Matsumoto Y; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Onda Y; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Tanaka K; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Kishimoto T; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Sato H; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Takemiya A; Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan., Sawasaki T; Division of Cell-Free Life Science, Proteo-Science Center, Ehime University, 3, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Feb; Vol. 133, pp. 118492. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2025.118492