Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.

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Title: Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.
Authors: Noordam R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Health Campus the Hague/Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.noordam@lumc.nl., Wang W; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Brown MR; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hui Q; Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA., Kraja AT; University of Mississippi Medical Center, Jackson, MS, USA., Morrison JL; Divison of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., O'Connel JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Lee S; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Biostatistics and Medicine, University of Washington, Seattle, WA, USA., de Las Fuentes L; Center for Biostatistics and Data Science, Institute for Informatics, Data Science and Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Feitosa MF; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hanfei X; Department of Biostatistics, Boston University, Boston, MA, USA., Harris SE; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Huang Z; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Kals M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lefevre C; Department of Bioinformatics, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Mangino M; Department of Twin Research, King's College London, London, UK., Milaneschi Y; GGZ inGeest, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, the Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Pacheco NL; National Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Rao V; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Sun Q; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Vojinovic D; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Wang Y; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany., Yang Q; MRC Integrative Epidemiology Unit at then University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhu W; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Aschard H; Institut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, 2115, USA., Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Assimes TL; Division of Cardiology, Department of Medicine, Palo Alto VA Healthcare System, Palo Alta, CA, USA; Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA, USA., Attia J; School of Medicine and Public Health, University of Newcastle, New Lambton Heights, Australia., Baker LD; Department of Internal Medicine (Geriatrics & Gerontology), Wake Forest University School of Medicine, Winston-Salem, NC, USA., Ballantyne C; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Bazzano L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Boerwinkle E; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Cade B; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Chen HH; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chen W; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Ida Chen YD; Department of Biostatistics, Boston University, Boston, MA, USA., Chen Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Cho K; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA., De Anda-Duran I; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Dimitrov L; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA., Edwards T; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Hingorani A; Faculty of Population Health, Institute of Cardiovascular Science, University College London, London, WC1E 6BT, UK., Fisher-Hoch SP; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Gaziano JM; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA., Gharib SA; Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., Giri A; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany., Graff M; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Charles Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Hixson J; Department of Epidemiology, UTHealth School of Public Health, Houston TX, USA., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA., Hood MM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Houghton SC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA., Karvonen-Gutierrez CA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 2142, USA., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lin HJ; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Linchangco GV Jr; Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA., Luik AI; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Ma J; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, 2111, USA., Meigs JB; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, USA., McCormick JB; School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA., Menni C; Department of Twin Research, King's College London, London, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Norris JM; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA., Petty LE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Polikowsky HG; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Riha RL; Department of Sleep Medicine, The University of Edinburgh, Edinburgh, UK., Russ TC; Alzheimer Scotland, Dementia Research Centre, The University of Edinburgh, Edinburgh, UK; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Ruiz-Narvaez EA; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconness Medical Center, Boston, MA, USA., Shen B; National Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA., Tang J; Department of Biostatistics, Boston University, Boston, MA, USA., Taylor KD; Division of Genomic Outcomes, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Triatin R; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Biomedical Sciences, Universitas Padjadjaran, Bandung, Indonesia., Tsai MY; Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Völzke H; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Westerman KE; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Xia R; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young KL; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Zhang R; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Zonderman AB; National Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA., Zhu X; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Below JE; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Evans M; National Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA., Fornage M; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA., Fox ER; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Franceschini N; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Harlow SD; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Holliday E; School of Medicine and Public Health, University of Newcastle, New Lambton Heights, Australia., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Kelly T; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Lawlor DA; MRC Integrative Epidemiology Unit at then University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Li C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Liu CT; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Manning AK; Massachusetts General Hospital, Clinical and Translational Epidemiology Unit, Department of Medicine, Boston, MA, 02114, USA; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Morrison AC; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Nauck M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., North KE; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Penninx BW; GGZ inGeest, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, the Netherlands., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Spector TD; GGZ inGeest, Amsterdam, the Netherlands., Wagenknecht LE; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands., Jaquish CE; Division of Cardiovascular Science, Epidemiology Branch, NHLBI, NIH, Bethesda, MD, 20817, USA., Wilson PW; Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Munroe PB; William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UK., de Vries PS; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Gauderman WJ; Divison of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Sun YV; Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA., Chen H; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Miller CL; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Corporate Authors: Lifelines Cohort Study; Roden, the Netherlands., Million Veteran Program
Source: Atherosclerosis [Atherosclerosis] 2026 Jan; Vol. 412, pp. 120603. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-1484
DOI:10.1016/j.atherosclerosis.2025.120603