Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.

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Title: Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.
Authors: Roddan R; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K., Schaich MA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC-Hillman Cancer Center, Pittsburgh, PA, 15232, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Kis I; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K., Pierangelini A; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, U.K., Henderson LR; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K., van Wee R; Physical and Theoretical Chemistry, Department of Chemistry, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.; Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX, U.K., Martin L; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K., El-Sagheer A; School of Chemistry, University of Southampton, SO17 1BJ, U.K., Kukura P; Physical and Theoretical Chemistry, Department of Chemistry, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Brown T; Chemistry Research Laboratory, 12 Mansfield Road, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, U.K., O'Brien D; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, U.K., Newman JA; Centre for Medicines Discovery, University of Oxford, NDMRB, Oxford, OX3 7DQ, U.K., Wilson DM 3rd; Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium., Schofield CJ; Chemistry Research Laboratory, 12 Mansfield Road, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, U.K.; Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, OX1 3TA, U.K., Van Houten B; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC-Hillman Cancer Center, Pittsburgh, PA, 15232, USA., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.
Source: Research square [Res Sq] 2025 Nov 17. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-7886236/v1