Phase 1 dose escalation trial of the selective adenosine A2B antagonist PBF-1129 in patients with metastatic non-small cell lung cancer.

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Title: Phase 1 dose escalation trial of the selective adenosine A2B antagonist PBF-1129 in patients with metastatic non-small cell lung cancer.
Authors: Owen DH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA. Dwight.owen@osumc.edu.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Dwight.owen@osumc.edu., Wu R; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Wei L; Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Dikov M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Suman S; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Su PL; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Check Kung University, Tainan, Taiwan., Amann J; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Guan S; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Spakowicz D; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Schweitzer C; Clinical Trials Office, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Pilcher C; Clinical Trials Office, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Smith MB; Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Ferguson S; Clinical Trials Office, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Palomino JC; Palobiofarma S.L., Pamplona, Spain., Pérez SF; Palobiofarma S.L., Pamplona, Spain., Bertino EM; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Shields PG; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., He K; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Presley CJ; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Otterson GA; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA., Carson WE; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Carbone DP; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 1800 Cannon Drive, 12th Floor, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Source: Investigational new drugs [Invest New Drugs] 2025 Dec; Vol. 43 (6), pp. 1211-1221. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-0646
DOI:10.1007/s10637-025-01591-y