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Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

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Title: Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.
Authors: Weerakkody TN; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Sabelström H; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Andrews SV; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Chadarevian JP; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA.; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Chin MY; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Propson NE; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Kim DJ; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Theolis R; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Parico GCG; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Misker H; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Kung JE; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Bandyopadhyay A; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Robles Colmenares Y; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Jackson TN; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Qerqez AN; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Balasundar S; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Davis SS; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Ghosh R; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Ravi R; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Germain K; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Tao A; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Xiong K; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Braun D; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Raju K; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Huang KC; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Zhan L; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Guo JL; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Safari Yazd H; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Sarrafha L; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Capocchi JK; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA., Hasselmann J; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Chadarevian AL; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Tu C; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Mansour K; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA., Eskandari-Sedighi G; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Tesi N; Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., van der Lee S; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., Hulsman M; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., Oshegov G; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., Calvert M; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Holstege H; Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands., Suh JH; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Davtyan H; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA 94080 USA., Blurton-Jones M; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA.; Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA.; Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA., Monroe KM; Denali Therapeutics Inc., South San Francisco, CA 94080 USA.
Source: Science translational medicine [Sci Transl Med] 2025 Dec 03; Vol. 17 (827), pp. eadw7428. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adw7428