The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism.

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Title: The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism.
Authors: Zhao Q; Department of Microbiology, University of Washington, Seattle, WA, USA., Vlach J; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Tan Y; Department of Biology, Saint Louis University, St. Louis, MO, USA., Bertolli SK; Department of Microbiology, University of Washington, Seattle, WA, USA., Srinivas P; Department of Microbiology, University of Washington, Seattle, WA, USA., Liao P; Department of Microbiology, University of Washington, Seattle, WA, USA., Fitzpatrick CR; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dangl JL; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Azadi P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., DiMaio F; Department of Biochemistry, University of Washington, Seattle, WA, USA; Institute for Protein Design, University of Washington, Seattle, WA, USA., Peterson SB; Department of Microbiology, University of Washington, Seattle, WA, USA., Zhang D; Department of Biology, Saint Louis University, St. Louis, MO, USA; Program of Bioinformatics and Computational Biology, Saint Louis University, St. Louis, MO, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Mougous JD; Department of Microbiology, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA; Microbial Interactions and Microbiome Center, University of Washington, Seattle, WA, USA. Electronic address: joseph.mougous@yale.edu.
Source: Cell [Cell] 2026 Jan 22; Vol. 189 (2), pp. 495-510.e20. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.10.044