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The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.

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Title: The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.
Authors: Carlson ES; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Haslecker R; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Lecchi C; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Aguilar Ramos MA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Vennelakanti V; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Honaker L; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Stornetta A; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Millán ES; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Johnson BA; Structural Biology Initiative, City University of New York (CUNY) Advanced Science Research Center, New York, NY, USA., Kulik HJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Balbo S; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Villalta PW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, USA., D'Souza VM; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Source: Science (New York, N.Y.) [Science] 2025 Dec 04; Vol. 390 (6777), pp. eady3571. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Carlson+ES%22">Carlson ES</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haslecker+R%22">Haslecker R</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lecchi+C%22">Lecchi C</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Aguilar+Ramos+MA%22">Aguilar Ramos MA</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vennelakanti+V%22">Vennelakanti V</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Honaker+L%22">Honaker L</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stornetta+A%22">Stornetta A</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Millán+ES%22">Millán ES</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+BA%22">Johnson BA</searchLink>; Structural Biology Initiative, City University of New York (CUNY) Advanced Science Research Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kulik+HJ%22">Kulik HJ</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Balbo+S%22">Balbo S</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Villalta+PW%22">Villalta PW</searchLink>; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22D'Souza+VM%22">D'Souza VM</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Balskus+EP%22">Balskus EP</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2025 Dec 04; Vol. 390 (6777), pp. eady3571. <i>Date of Electronic Publication: </i>2025 Dec 04.
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