Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses.
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| Title: | Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses. |
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| Authors: | Dunwoodie L; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States., Huang M; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, United States., Moore AR; Stanford Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, United States.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, CA, United States., Stanski NL; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Standage SW; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Kaplan JM; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Zingarelli B; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Harmon K; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Fitzgerald JC; Children's Hospital of Philadelphia, Philadelphia, PA, United States., Weiss SL; Nemours Children's Hospital, Wilmington, DE, United States., Bigham MT; Akron Children's Hospital, Akron, OH, United States., Schwarz AJ; Children's Hospital of Orange County, Orange, CA, United States., Lutfi R; Riley Hospital for Children, Indianapolis, IN, United States., Thomas NJ; Penn State Hershey Children's Hospital, PA, United States., Haileselassie B; Lucile Packard Children's Hospital Stanford, Palo Alto, CA, United States., Jain PN; Heart Center, Children's Health, Division of Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States., Sweeney TE; Inflammatix, Sunnyvale, CA, United States., Kamaleswaran R; Department of Surgery, Duke University School of Medicine, Durham, NC, United States., Atreya MR; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Lautz AJ; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1663704. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1663704 |
