Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals.

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Title: Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals.
Authors: Liedes O; Finnish Institute for Health and Welfare, Helsinki, Finland. oona.liedes@thl.fi., Reinholm A; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland., Ekström N; Finnish Institute for Health and Welfare, Helsinki, Finland., Haveri A; Finnish Institute for Health and Welfare, Helsinki, Finland., Solastie A; Finnish Institute for Health and Welfare, Helsinki, Finland., Vara S; Finnish Institute for Health and Welfare, Helsinki, Finland., Rijnink WF; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Bestebroer TM; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Richard M; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., de Vries RD; Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands., Jalkanen P; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland., Lindh E; Finnish Institute for Health and Welfare, Helsinki, Finland., Ikonen N; Finnish Institute for Health and Welfare, Helsinki, Finland., Grifoni A; Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA., Sette A; Center for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Laaksonen T; Finnish Food Authority, Helsinki, Finland., Holopainen R; Finnish Food Authority, Helsinki, Finland., Kakkola L; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Lappalainen M; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland., Syrjänen RK; Finnish Institute for Health and Welfare, Helsinki, Finland.; FVR - Finnish Vaccine Research, Tampere, Finland., Kolehmainen P; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland., Julkunen I; Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Nohynek H; Finnish Institute for Health and Welfare, Helsinki, Finland., Melin M; Finnish Institute for Health and Welfare, Helsinki, Finland.
Source: Nature microbiology [Nat Microbiol] 2026 Jan; Vol. 11 (1), pp. 155-168. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-025-02183-5