The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression.

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Title: The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression.
Authors: Schiweck C; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Aichholzer M; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Brandt E; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Schneider M; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Meyer K; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Hamzehloiya T; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Qubad M; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Ernst Strüngmann Institute for Neuroscience (ESI) in Cooperation with Max Planck Society, Frankfurt am Main, Germany., Uckermark C; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Jacobsen L; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Amaral K; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Auer J; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Bruno G; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Zhao T; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Bouzouina A; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Schillo S; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Hanssen R; University of Cologne Faculty of Medicine and University Hospital Cologne, Policlinic for Endocrinology, Diabetology and Preventive Medicine (PEPD), Köln, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany., Hahn T; University of Münster, Institute for Translational Psychiatry, Münster, Germany., Repple J; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Matura S; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany., Kingslake J; P1vital Products Limited, Howbery Park, Wallingford, Oxfordshire, UK., Reif A; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany., Edwin Thanarajah S; Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany. edwinthanarajah@med.uni-frankfurt.de.; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany. edwinthanarajah@med.uni-frankfurt.de.; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany. edwinthanarajah@med.uni-frankfurt.de.
Source: Translational psychiatry [Transl Psychiatry] 2025 Dec 06; Vol. 15 (1), pp. 521. Date of Electronic Publication: 2025 Dec 06.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-025-03780-y