Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines.

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Title: Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines.
Authors: Cui X; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Amelinck L; Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Biotechnology, Ghent University, Ghent, Belgium., Gillon O; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Catani JPP; Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Biotechnology, Ghent University, Ghent, Belgium., Gao Y; Department of Translational Physiology, Infectiology and Public Health, Ghent University, Merelbeke, Belgium., Sun Q; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., De Sutter E; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Vervaeke P; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Snoeck J; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Lienenklaus S; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany., Saelens X; Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Biotechnology, Ghent University, Ghent, Belgium., Zhong Z; Department of Pharmaceutics, Ghent University, Ghent, Belgium. zifu.zhong@ugent.be.; Cancer Research Institute (CRIG), Ghent University, Ghent, Belgium. zifu.zhong@ugent.be., Sanders NN; Laboratory of Gene Therapy, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. niek.sanders@ugent.be.; Cancer Research Institute (CRIG), Ghent University, Ghent, Belgium. niek.sanders@ugent.be.
Source: Nature communications [Nat Commun] 2025 Dec 06; Vol. 17 (1), pp. 278. Date of Electronic Publication: 2025 Dec 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-66993-1